Serum cold-inducible RNA-binding protein (CIRP) levels as a prognostic indicator in patients with acute ischemic stroke

Background Acute ischemic stroke (AIS) is the leading cause of morbidity and mortality among cerebrovascular diseases. While animal studies have suggested a correlation between cold-inducible RNA-binding protein (CIRP) serum levels severity prognosis cerebral infarction, there has been lack research exploring this association in humans with infarction. Materials methods A total 148 patients diagnosed AIS within 7 days from symptom onset were included study. Comprehensive information regarding patients' basic demographics, medical history, clinical parameters, CIRP was collected. Follow-up data obtained through telephonic interviews or by reviewing notes for 3 months after discharged to assess functional outcomes treatment. Results The findings study demonstrated significant increase during early stages AIS, followed gradual decline days. Significant differences observed 1-day group 4–7 day ( P < 0.0047), as well 2–3 0.0006). Moreover, positive Higher associated more severe National Institutes Health Stroke Scale scores 0.05) larger infarction volumes 0.05). Furthermore, higher exhibited poorer modified Rankin scale These indicate that serves an essential pro-inflammatory mediator valuable biomarker assessing brain injury AIS. Conclusion suggest elevation are positively correlated serve indicators poor prognosis. Therefore, could target intervention while managing further should explore prognostic